The Prince House fronts east onto the street. It is two bays wide in an L plan, forming a right (north) projecting gable front and a left (south) wing with a shed-roof porch. An original rear single-pile ell extends west from the south wing, which was lengthened in 1935 to include a rear stairway to a hipped-roof second story that was added over the ell. The front-gabled north wing is double pile. The side-gabled south wing is single pile. The house sits on locust piers and a dry-laid stone foundation. The exterior of the house has minimal ornament. The walls are clad with plain poplar weatherboards, and the central interior capped chimney is built of stone with a stucco finish. A second interior chimney in the ell is constructed of brick. The two-over-two lite double-hung wood sash windows, the majority of which are paired, have plain board surrounds and wood drip caps with mostly pegged corners, mortise and tenon joints, and slender exterior muntins. The multi-gabled roof is covered by pressed metal shingles and the central chimney is stuccoed.
This exterior description is arranged in a counter-clockwise review of the walls of the house. The east elevation contains a left (south) wing and a right (north) projecting gable front. The gable features on each story a pair of double sash windows. Over the shed porch in the wing is a single square sash containing two vertical lites. The porch floorboards are yellow pine accessed by wide dressed-granite steps. The porch roof, supported by square posts attached to an unornamented balustrade, shelters two front entrances: a main entry into the wing and a side entry into the gable. The south front door contains two-over-two lites with slender muntins above two raised horizontal panels and a cast-iron oval knob, escutcheon, and mortised lock. The north porch door, which provides a separate entrance to a front bedroom, features two-over-two lites above two square-edge vertical panels and a white porcelain doorknob. The entrance surrounds of both porch doors are composed of four-and-one-half-inch plain casings. The doors are protected by wood-framed screen doors reinforced with flush wooden corner bracing. The south screen door is hung on cast-iron spring hinges.
The north elevation of the front block is two bays wide. Each bay of the first story contains a double sash window. Similarly spaced on the second level were two windows original to 1877, which were boarded over with weatherboard in-fill in 1935, leaving only the surrounds. The west (rear) elevation of this gabled section is similar to the east (front) fa ade, featuring a pair of two-over-two windows. The north elevation of the rear ell is set back from the north elevation of the front-gabled bay and features a two-over-two window with narrow muntins on the second story above a pair of small four-over-one vertical sash double hung paired windows, dating from 1935. A two-over-two window with narrow muntins is located at the west end of the wall.
The west elevation of the two-story rear ell is a blind wall with no windows. The south elevation of the house is composed of two sections: the ell to the west and the side-gabled wing to the east. The west end of the ell features on the first story a single square sash containing two vertical lites. East of it is a two-over-two window, above which is a pair of two-over-two double-hung sashes. Access to the ell is through a recessed side entrance. The original door, similar to an original four-panel door stored in the cellar, contains four cove-edge vertical panels, a glass knob, and a mortised lock. It is protected by a screen door of the same square-edge style as the one at the north end of the front porch. Above this side porch is a two-over-two window. In the south elevation of the front block are two-over-two windows in pairs on each level. A small vertical-four-over-one lite double hung sash window, dating from 1935, is located to the west of the paired windows in the first and second levels and roughly centered between the two stories. This window lights the interior stair landing.